Is my Lp(a) (Lipoprotein(a)) normal?
Free blood test checker · Standard + longevity-optimal ranges
What is a normal Lp(a) level?
Lp(a) is a predominantly genetic lipoprotein particle — approximately 90% determined by the LPA gene — that is structurally similar to LDL but carries an additional apolipoprotein(a) chain. It is an independent risk enhancer for atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis. Unlike LDL cholesterol, Lp(a) is largely unresponsive to statins, diet, or standard lifestyle changes. Levels remain stable throughout life. High-risk threshold is > 50 mg/dL (or > 125 nmol/L), which confers risk equivalent to heterozygous familial hypercholesterolemia. The European Atherosclerosis Society recommends measuring Lp(a) at least once in every adult.
| Range | Values |
|---|---|
| Standard Reference | 0–75 nmol/L |
| Optimal | 0–30 nmol/L |
| Longevity Optimal | < 50 mg/dL |
| High Risk | > 125 nmol/L |
What causes abnormal Lp(a) levels?
Lp(a) levels are >90% determined by genetics — specifically the LPA gene. Unlike LDL, diet, exercise, and most medications have minimal impact on Lp(a). Niacin can reduce Lp(a) by 20-30% but is not recommended due to side effects. PCSK9 inhibitors lower Lp(a) modestly (20-25%). Statins paradoxically increase Lp(a) slightly. Ethnicity matters: people of African descent tend to have higher Lp(a) levels than those of European descent.
When should you see a doctor?
See your doctor if Lp(a) is above 75 nmol/L (30 mg/dL), especially if you have a family history of premature heart disease or stroke. If above 125 nmol/L (50 mg/dL), discuss aggressive cardiovascular risk mitigation including lower LDL/ApoB targets and potential aspirin therapy. Every adult should be tested at least once.
Lp(a) and longevity
Lp(a) is arguably the most important cardiovascular biomarker that most people have never tested. Because it is genetically determined and stable over a lifetime, a single measurement provides permanent risk stratification. Elevated Lp(a) contributes to atherosclerosis through three distinct mechanisms: it carries atherogenic cholesterol into arterial walls like LDL, it promotes thrombosis by competitively inhibiting plasminogen activation (impairing clot breakdown), and it triggers arterial wall inflammation. Mendelian randomization studies confirm that lifelong elevated Lp(a) dramatically increases risk of myocardial infarction, stroke, and calcific aortic valve stenosis. Phase 3 trials of antisense oligonucleotide therapies (pelacarsen, olpasiran) show 80-90% Lp(a) reduction and may transform management within 2-3 years.
Where to get a Lp(a) test
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Related biomarkers
These biomarkers are often tested alongside Lp(a) for a more complete picture.
Frequently asked questions
What is a normal Lp(a) level?
Can I lower my Lp(a)?
Why should I test Lp(a)?
How does Lp(a) differ from LDL?
Can you lower Lp(a) with diet or statins?
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Sources: Reference ranges based on AHA/ACC, ADA, and AACE clinical guidelines. Biological variation data from Ricos/Westgard database. Longevity-optimal ranges reflect targets used by preventive and functional medicine practitioners.
Last reviewed: April 2026. This tool provides general health information and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider about your specific results.