Is my Total Protein normal?
Free blood test checker · Standard + longevity-optimal ranges
What is a normal Total Protein level?
Total protein measures the combined amount of albumin and globulin in your blood. Normal range is 6.0-8.3 g/dL. Albumin is produced by the liver and maintains blood volume; globulins include antibodies and transport proteins. Abnormal total protein can indicate liver disease, kidney disease, malnutrition, or immune disorders.
| Range | Values |
|---|---|
| Standard Reference | 6–8.3 g/dL |
| High Risk | > 9.5 g/dL |
| Low Risk | < 5 g/dL |
What causes abnormal Total Protein levels?
Low total protein is caused by liver disease (cirrhosis reduces albumin synthesis), nephrotic syndrome (protein lost in urine), malabsorption (celiac disease, IBD), malnutrition, extensive burns, and hemorrhage. High total protein is caused by chronic infections (HIV, hepatitis), autoimmune diseases, multiple myeloma (monoclonal immunoglobulin spike), dehydration (hemoconcentration), and chronic inflammatory conditions.
When should you see a doctor?
See your doctor if total protein is below 5.0 g/dL or above 9.5 g/dL. Also consult if total protein is persistently abnormal even mildly, especially with edema, foamy urine, fatigue, or unexplained weight loss. Serum protein electrophoresis (SPEP) may be needed to identify the specific protein abnormality.
Total Protein and longevity
Total protein is a broad screening marker that reflects the synthetic capacity of the liver and the state of the immune system. In aging populations, declining albumin is one of the strongest predictors of all-cause mortality and frailty. Maintaining adequate protein intake (1.2-1.6 g/kg/day for older adults) and preserving liver function are essential for healthy aging. The albumin/globulin ratio provides additional nuance — a low ratio may signal chronic inflammation or immune activation.
Where to get a Total Protein test
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Related biomarkers
These biomarkers are often tested alongside Total Protein for a more complete picture.
Frequently asked questions
What is a normal total protein level?
What is the difference between albumin and globulin?
What causes low total protein?
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Sources: Reference ranges based on AHA/ACC, ADA, and AACE clinical guidelines. Biological variation data from Ricos/Westgard database. Longevity-optimal ranges reflect targets used by preventive and functional medicine practitioners.
Last reviewed: April 2026. This tool provides general health information and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider about your specific results.