eGFR Calculator (CKD-EPI)

Free health calculator · eGFR (estimated Glomerular Filtration Rate) measures how well your kidneys filter waste. This calculator uses the race-free CKD-EPI 2021 equation, the current clinical standard that replaced the older race-based formula.

Formula

CKD-EPI 2021: 142 × min(Cr/κ, 1)^α × max(Cr/κ, 1)^-1.200 × 0.9938^Age × (1.012 if female)

Creatinine (mg/dL)

Age (years)

Sex

What is eGFR?

eGFR above 90 is normal. 60-89 is mildly decreased (common with aging). Below 60 on two tests three months apart defines chronic kidney disease (CKD). The CKD-EPI 2021 equation replaced the older race-based formula. 37 million Americans have CKD, and 90% are undiagnosed. Diabetes and hypertension are the leading causes.

eGFR and longevity

Kidney function is a cornerstone of longevity. The cardiovascular-kidney-metabolic (CKM) syndrome framework recognizes that heart disease, kidney disease, and metabolic dysfunction form a self-reinforcing triad. NSAIDs are among the most common reversible causes of eGFR decline. Maintaining eGFR above 90 through blood pressure control, hydration, and avoiding nephrotoxins is a core longevity strategy.

Related biomarkers

These biomarkers are used in or related to the eGFR calculation.

Frequently asked questions

What is a normal eGFR?

Normal eGFR is above 90 mL/min/1.73m². Stage 2 CKD: 60-89. Stage 3: 30-59. Stage 4: 15-29. Stage 5 (kidney failure): below 15. eGFR naturally declines about 1 mL/min/year after age 40.

Why was the race variable removed from eGFR?

The CKD-EPI 2021 equation removed the race coefficient that had been used since 2009. Studies showed the race adjustment was not biologically justified and led to systematic underdiagnosis of CKD in Black patients. The new equation uses only creatinine, age, and sex.

Can exercise affect my eGFR?

Intense exercise can temporarily raise creatinine (which lowers calculated eGFR) for 24-48 hours. For accurate results, avoid heavy exercise before blood draws. High muscle mass can also chronically elevate creatinine, making eGFR appear lower than true kidney function. Cystatin C-based eGFR is more accurate for muscular individuals.

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Check all your biomarkers at once

Upload any blood test PDF and get your complete BioMap — a visual map of every biomarker in your panel. Free, instant, no account required.

Upload your labs — Get your BioMap

Sources: eGFR formula based on published peer-reviewed research. Reference thresholds from clinical guidelines.

New Creatinine- and Cystatin C-Based Equations (CKD-EPI 2021) — NEJM

Last reviewed: April 2026. This calculator provides general health information and is not a substitute for professional medical advice, diagnosis, or treatment.

eGFR Calculator (CKD-EPI)

Formula

CKD-EPI 2021: 142 × min(Cr/κ, 1)^α × max(Cr/κ, 1)^-1.200 × 0.9938^Age × (1.012 if female)

Creatinine (mg/dL)

Age (years)

Sex

What is eGFR?

eGFR and longevity

Frequently asked questions

What is a normal eGFR?

Normal eGFR is above 90 mL/min/1.73m². Stage 2 CKD: 60-89. Stage 3: 30-59. Stage 4: 15-29. Stage 5 (kidney failure): below 15. eGFR naturally declines about 1 mL/min/year after age 40.

Why was the race variable removed from eGFR?

Can exercise affect my eGFR?

Check all your biomarkers at once

Upload any blood test PDF and get your complete BioMap — a visual map of every biomarker in your panel. Free, instant, no account required.

Upload your labs — Get your BioMap

Sources: eGFR formula based on published peer-reviewed research. Reference thresholds from clinical guidelines.

New Creatinine- and Cystatin C-Based Equations (CKD-EPI 2021) — NEJM

Last reviewed: April 2026. This calculator provides general health information and is not a substitute for professional medical advice, diagnosis, or treatment.